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Centre of Sustainable Chemistry

Reaction and Process Design

  • COILSIM1D: simulation and optimization software for steam cracking processes
  • GCxGC analysis equipment for complex mixtures of feed/reaction products
  • Bench scale units for kinetic experiments
  • Temporal Analysis of Products (TAP) for puls-respons experiments
  • Two high-throughput kinetics set-ups for catalyst testing
  • Pyrolysis reactors for the thermochemical conversion of biomass
  • Microreactor equipment
  • CFD simulation tools
  • Tools for exergetic sustainability and life-cycle assessments

Industrial Biotech

  • Enzyme engineering: specialized software for protein modeling and docking (Yasara Structure)
  • Automated screening platform: high-throughput robots for colony picking and for liquid handling; microplate reader
  • Microbiology/molecular biology: PCR; electrophoresis; electroporation; laminar flow; bioreactors with shaking, T-control and data acquisition software; Bioscope Plug-flow reactor for rapid sampling experiments; Metabolic Flux Analysis Software (MFA); software for DNA and RNA analysis; …
  • Purification/DSP (downstream processing): evaporators; (continuous) centrifuges; lyophilisator; …
  • Product analysis: GC/HPLC with UV-VIS, IR, PAD, ELSD and MS detection
  • Microbial electrochemistry: rotating disc electrode for probing kinetics of anaerobic microbial metabolism; membrane electrolysis materials such as a potensiostat, custom-made Perspex plate-and-frame reactor, ion exchange membranes, iridium oxide coated titanium anodes, variety of cathode materials

Advanced Materials

  • Molecular characterization: structure elucidation with NMR, MALDI-TOF, on-line IR, GC- and LC-MS analysis, chiral HPLC, …
  • Structural characterization: determination of molecular weight and molecular weight distribution of polymers via SEC and 2D LC/SEC; microstructural and crystallographical analysis of powders and thin layers; texture analysis; …
  • Behaviour of solutions via turbidimetry, light scattering, determination of particle size, viscosimetry, …
  • Surface visualization and characterization: measurement of microscopic features and microstructures at nanoscale supported by optical microscopy, SEM, TEM, AFM, IR mapping, XRD, XPS; surface interaction via static and dynamic contact angle measurements; quartz crystal microbalance-coupled ellipsometry
  • Thermal and mechanical analysis: study of thermal behaviour via differential scanning calorimetry (DSC) and thermogravimetric analysis (TGA); study of mechanical behaviour via dynamic mechanical analysis (DMA), rheology and materials testing equipment

The Pilot Steam Cracker

LCT disposes of a pilot plant unit for the thermal cracking of hydrocarbons, next to a number of bench-scale units. These experimental set-ups are used to determine the kinetics of the cracking reactions and of coke deposition in both the radiant coil and the transfer line exchanger (TLE). Fouling inhibition in reactor and TLE is also studied. Major advantage of the pilot unit is its extremely flexibility. A wide variety of hydrocarbons, ranging from gaseous feeds to waxes, can be handled. Moreover, the reactor design allows to obtain a broad range of process conditions. The pilot plant also offers the opportunity to industrial groups to test industrially important and/or new feeds, additives, coatings etc. in pilot plant experiments done by LCT personnel.

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    Material characterization

    COURSE OVERVIEW

    This course gives an introduction on the (pharmaceutical) relevance of (raw) material characterization. An overview is given about the relevant characterization methods on the market, their applicability and how the material properties can be used to describe the processability.
    This 1-day course consists out of a theoretical (interactive) and hands-on part.


    MODULE 1: BASIC COURSE

    Theoretical

    The trainee will get an in-depth explanation about the different characterization methods, their (pharmaceutical) relevance and what you can do with the generated data.
    Some of the key material characteristics described are:

    Flow/cohesion
    &
    Particle size and shape
    &
    Density and porosity
    &
    Electrostatic charge
    &
    Melting point and crystal structure
    &
    Viscosity

    Practical

    Hands-on sessions will allow the trainee to get a feel with what it takes to characterize a material.
    The extensive array of characterization equipments, available at CESPE, will be made available to visualize the difference between highly divergent powders.
    Some of the equipment that will be used are:

    FT4 Powder Rheometer
    &
    Schulze Ring Shear Tester
    &
    GranutoolsTM equipment
    &
    Malvern Laser diffractors
    &
    DVS and DSC equipment

    Upon request, a powder of interest could be tested on the available equipment!
    For more information, please contact Sarah.Costers@UGent.be .


    COURSE PROGRAMME

    A detailed overview of the course can be found in the following document.


    If you are interested in taking this course, please email Mark (mark.gontsarik@ugent.be).

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    Dr. Frank Deruyck

    PRINCIPAL INVESTIGATOR

    University College Ghent
    Department of Chemistry
    Valentin Vaerwyckweg 1
    B-9000 Gent, Belgium

    Frank.Deruyck@hogent.be

    +32 478 49 15 40

    Frank obtained his Ph.D. in Chemistry at UGent in 1988 and began an industrial career in Bekaert Technology Centre as an R&D manager, process development engineer, and finally global process owner in wet drawing lubrication and steel cord – rubber adhesion. His main responsibilities were leading Operation Excellence (OPEX) and product development projects. In this position he gained a wide experience in quality improvement tools, statistical data analysis, modelling and design of experiments. Achieving key process improvement projects goals Frank got qualified as an ASQ Certified Six Sigma Black Belt by American Society for Quality. After a successful period in the industry, he was a trainer of Green Belt and Lean Six Sigma in pharma industry as an independent consultant in R&D support and Design of Experiments.

    At HOGENT for 10 years now, Frank teaches TQM, Chemometrics, Applied Statistics and Industrial Chemistry. His mission is to put professional experience at the service of the next generation of junior engineers and managers. Frank is also a member of the HOGENT Centre of Applied Data Science platform that provides support in data processing to a variety of industrial service and R&D projects. In the JMP User Community he participates in instructive discussions about statistical data analysis and present case studies on discovery summits.

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    CADS

    Field of Expertise:
    Applied Data Sciences

    The Centre for Applied Data Science (CADS) has an extensive experience in the field of data sciences, including:

    • Statistical analysis process and R&D data

    – Regression analysis and statistical modeling
    – Predictive modeling: Machine Learning (neural/boosted tree/boat step forest)
    – Multivariate analysis: PCA/Factor Analysis/Clustering
    – Time-series analysis

    • Experimental planning using (AI based) Optimal Design of Experiments (DOE)
    • Quality & Process control

    Above statistical methods are applied to:
    – Monitoring, assessing stability and performance of production processes
    – Optimization and validation of measurement systems
    – Modeling of industrial processes, determining “Design Space” & optimal process parameter control ranges