Takeda Lessines and Ghent University’s Innovation Cluster CESPE Enter into Pharmaceutical Manufacturing Innovation Partnership

Ghent (March 25, 2021) – Takeda and Ghent University (UGent) are pleased to announce that Takeda’s Global Manufacturing Site at Lessines has officially joined the CESPE innovation cluster, a multi-partner innovation accelerator in the field of pharmaceutical engineering and manufacturing. This strategic partnership reflects both parties’ strong desire to further intensify their research and innovation efforts and to make optimal use of the cross pollination between industry and academia. Initially, this partnership will focus on optimising digitization in Pharma 4.0, pharmaceutical technology innovation, and optimising energy and material efficiency during production.

“As one of the global leaders in the production of plasma derivatives, Takeda continuously improves its manufacturing operations. To this end, the mutual sharing of knowledge with other companies and knowledge institutions like CESPE is key”

— Gert Verheyden, Head of Manufacturing Sciences at Takeda Lessines —

“As one of the global leaders in the production of plasma derivatives, Takeda continuously improves its manufacturing operations. To this end, the mutual sharing of knowledge with other companies and knowledge institutions like CESPE is key”, says Gert Verheyden, Head of Manufacturing Sciences at Takeda Lessines. “This allows Takeda Lessines to make a significant contribution to the training of tomorrow’s pharmaceutical engineers, both in existing and emerging education tracks, and also to increase the industrial relevance of possible innovation projects at the international level.” “We are thrilled to collaborate with Takeda and to thus facilitate its strong desire to implementing innovative production processes of active pharmaceutical ingredients and finished pharmaceutical products. We are collaborating precompetitively with an industrial network to build a strong knowledge region enabling the local anchoring of talent and innovation”, says professor Thomas De Beer, Director of CESPE.

Copyright Takeda

 About Takeda

Takeda Pharmaceutical Company Limited (TSE:4502/NYSE:TAK) is a global, values-based, R&D-driven biopharmaceutical leader headquartered in Japan, committed to discover and deliver life-transforming treatments, guided by our commitment to patients, our people and the planet. Takeda focuses its R&D efforts on four therapeutic areas: Oncology, Rare Genetic and Hematology, Neuroscience, and Gastroenterology (GI). We also make targeted R&D investments in Plasma-Derived Therapies and Vaccines. We are focusing on developing highly innovative medicines that contribute to making a difference in people’s lives by advancing the frontier of new treatment options and leveraging our enhanced collaborative R&D engine and capabilities to create a robust, modality-diverse pipeline.

Our employees are committed to improving quality of life for patients and to working with our partners in health care in approximately 80 countries.

For more information, visit

About UGent-CESPE

Ghent University (UGent) is a top 100 university and one of the largest Belgian universities in the heart of Europe. It is an active partner in national and international educational, scientific and industrial cooperation. The organization is committed to research and innovation with an annual research budget of more than € 600 million and more than 5,500 researchers active in a wide range of the life, physical and social sciences. UGent TechTransfer and the UGent Business Development Platforms, such as CESPE, support researchers in developing groundbreaking science to bring innovations to the market.

The Centre of Excellence in Sustainable Pharmaceutical Engineering and Manufacturing (CESPE) is a multidisciplinary innovation accelerator hosted at Ghent University focusing on the sustainable development, design and optimization of both drug substance and drug product production platforms. Its ambition is to become the reference centre in end-to-end (bio)pharmaceutical manufacturing in Europe. It accelerates the development of emerging production technologies to manufacture the medicines of the future in a sustainable, agile way.

For more information, visit

Media Contact:

Stefaan Fiers, Head of Corporate Communication
Tel: 0476 76 90 77

Wouter De Soete, Manager
Tel: 0474 80 65 67


Partner simAbs is hiring

Great job opportunity! Want to develop your Process Development Engineering skills? Our partner simAbs, developing a new biopharmaceutical manufacturing platform, might have just the challenge you’re looking for! Check out the job offer here!


CESPE Industrial Partnering Day


Did you miss any of the presentations during the CESPE Industrial Partnering Day 2020?
Review them here! Full stream available!


Rik Van de Walle, Ghent University, Rector
Sofie Bracke, City of Ghent, Alderman for Economy, Trade, Sport & Port

Introduction to CESPE

Introduction to CESPE (Wouter De Soete, CESPE Manager)

Keynote “Belgian Biotech: Evolution & Revolution”

Geoffrey Pot, Chairman of the Board, Takeda Site Head, VP Operations

Industry Testimonial: Janssen Pharmaceutica

Jan Van der Goten, Head of Strategic Campus Office, Janssen Pharmaceutica

Research and Innovation pitches

Prof. Chris Stevens, Microreactor Technology: One Flow, One Product
Prof. Thomas De Beer, Prof. Ingmar Nopens, The Future of Pharmaceutical Drug Product Manufacturing
Prof. Richard Hoogenboom, Poly(2-oxazoline)s as Novel Excipients for Oral Formulations
Prof. Ludwig Cardon, 3D Printing: An Innovative Manufacturing Method
Prof. Kevin Van Geem, Maarten Dobbelaere, Artificial Intelligence for Computer-Aided Synthesis in Flow
Prof. Joris Thybaut, Chemical Reactor Performance Assessment and Innovation by Modeling
Prof. Jo Dewulf, Sustainability Assessment in Pharmaceutical Manufacturing
Prof. Dieter Claeys, Jeroen De Maeyer, Industry 4.0 Operational Excellence for Pharma 4.0

Company pitches

Koen Dierckx, simAbs, CEO, Integrated Continuous Bioprocessing of Monoclonal Antibodies
Pieter-Jan Van Bockstal, RheaVita, Project Manager Technology, A Continuous Freeze-Drying Technology for Fast, Flexible and High Quality Manufacturing of Biopharmaceutical Products

CESPE industrial partnering day


SAVE THE DATE for the first CESPE Industrial Partnering Day!
December 2nd, 2.00pm – 5.00pm
Feel free to forward within your organisation 

Interested in how Ghent University accelerates innovation and cultivates partnerships in Sustainable Pharmaceutical Engineering and Manufacturing? Innovating in the pharmaceutical or biotech industry? Equipment, infrastructure developer or system integrator? We gladly introduce you to CESPE and provide you with a selection of high-quality R&I pitches from both UGent and industry!


  • UGent rector Rik Van de Walle
  • Deputy mayor of the City of Ghent Sofie Bracke
  • World class industry leaders: Janssen Pharmaceutica and Takeda.

Register now to receive your personal invite and program updates on the Keynote and pitching sessions!

Free of charge. Registration is closed.

End-to-end integrated pharmaceutical manufacturability of tomorrow’s medicines – Enabling sustainable innovation in drug substance and drug product production.


PHD position open in pharmaceutical technology!

Fascinated by pharmaceutical process development and how novel drug manufacturing techniques contribute to that? Eager to pursue a PhD in Pharmaceutical Sciences on the industrial implementation of continuous tablet manufacturing via direct compression?

This could be your opportunity! A collaboration between Ghent University CESPE and Johnson and Johnson Belgium!

More information on the topic and how to apply on the UGent Job portal!

Short project description

The pharmaceutical industry is switching from batch-wise to continuous manufacturing of tablets. The aim of current project is to address crucial gaps of knowledge for industrial implementation of continuous tablet manufacturing via direct compression.

During drug product development limited amounts of new chemical entities are available to investigate the effect of formulation and process variables on the final drug product. The first aim is therefore to develop a strategy for identification of a surrogate component, i.e. a component with similar characteristics as the new chemical entity, to use during early process and formulation development trials. Furthermore, continuous feeding of very cohesive raw materials is often challenging and affects further downstream processing. Therefore, various formulation strategies to overcome feeding issues of very cohesive raw materials in function of process parameters will be developed. Finally, a control strategy based on residence time distributions is of utmost importance to ensure the final product quality and traceability along the manufacturing line. Therefore, the critical formulation and process parameters affecting residence time distributions on a continuous direct compression line will be investigated and predictive models will be built for each unit operation and for the integrated line.



Interested in the capabilities of continuous freeze-drying? What is the impact on stability, supply chain, manufacturing operations, quality control, etc.?

Subscribe to the hands-on workshop on batch versus continuous freeze-drying of pharmaceuticals!

  • Demonstration of continuous freeze-drying prototypeF
  • Formulation characterization for batch and continuous freeze-drying hands-on training
  • DEMO PAT for continuous freeze-drying
  • Dynamic design space determination
  • Execution of batch and continuous freeze-drying processes for selected formulations
  • Evaluation performed batch and continuous freeze drying runs
  • Determination CQAs freeze-dried products: batch versus continuous


CESPE will present to you at Knowledge for Growth 2018 this week Thursday 17th in Ghent #KfG2018! Visit us at exhibition booth 75, first floor of TTO Flanders Ghent University Tech Transfer to get to know more about the Centre of Excellence in Sustainable Pharmaceutical Engineering. #KfG2018 with