Twin screw granulation 101 focusses on giving a thorough introduction about the granulation process in an interactive manner (both theoretical and hands-on).
This course can be divided into three separate modules:
Module 1: Basic course: Introduction to twin screw wet granulation (1-day module)
Module 2: Basic course: Introduction to twin screw hot-melt granulation (1/2-day module)
Module 3: Specialized courses (1/2-day module)
MODULE 1: WET GRANULATION
The trainee will get an in-depth explanation about the basic twin screw wet granulation aspects such as:
Principles of wet granulation
Batch vs continuous manufacturing
Process and formulation parameters
The in-house ConsiGmaTM -25 line will be used to demonstrate the twin screw wet granulation process. Afterwards, the produced granules will be tested using the available granule characterization methods.
The hands-on session consists out of:
ConsiGmaTM-25 demonstration with placebo
Introduction to granule characterization methods
MODULE 2: HOT-MELT GRANULATION
The trainee will get an in-depth explanation about the basic twin screw hot-melt granulation aspects such as:
Fundamentals of hot-melt granulation
Equipment configurations and settings
*Will be skipped if module 1 was followed as well.
The trainee will be able to follow and help during placebo trials using a twin screw hot-melt granulator. The influence of process and formulation parameters will be demonstrated.
MODULE 3: SPECIALIZED COURSES
In this module, the goal is to highlight specific aspects of the granulation process through different use-cases. Each use-case allows the trainee to get an in-depth comprehension of a specific part of the process.
Wet granulation: Modified release formulations
Wet granulation: Impact of dry or wet addition
The trainee has the option to take up all of the provided topics, covering a half day course, or select a sub-set of these topics.
A detailed overview of the different modules can be found in the following document.