At BIOMATH we develop and apply mathematical models and methodologies for the analysis and optimization of (bio)processes. The primary focus is on mechanistic models used to support a variety of priority sectors such as pharmaceutical manufacturing technology. BIOMATH has gained expertise in the fields of computational fluid dynamics, population balance modelling and bio-kinetics.
EnVOC focuses their research, education and service activities on environmental and sustainability issues of organic chemistry and technology.
The Laboratory of Process Analytical Technology (LPPAT) focuses on the implementation of PAT systems in innovative pharmaceutical production processes and therefore has always worked in close collaboration with the Laboratory of Pharmaceutical Technology of Prof. Dr. C. Vervaet and is part of the QbD and PAT Sciences Network.
The Particle and Interfacial Technology Group (PaInT) is a research group within the Faculty of Bioscience Engineering at Ghent University, which focuses on characterization and practical applications of particles and interfacial phenomena and technology. We are currently applying our know-how in the fields of:
- Physico-chemical water treatment
- Formulation of (multiple) emulsions
- Membrane-based processes
- Surfactant behaviour in aqueous media with specific focus on vesicles
An important application on the interfacial phenomena and technology side is physico-chemical treatment of drinking, waste- and process water streams, with the majority of the projects focusing on drinking- and process water treatment.
Besides, the PaInT group has been involved for several decades in research related to preparation, stabilization, characterization and application of dispersed systems, such as (nano)suspensions, (multiple) emulsions, and vesicular dispersions. As far as characterization is concerned, the group has built up experience with several particle sizing techniques, including dynamic light scattering, laser diffraction, pfg-NMR, electrical sensing zone, Time-of-Transition, Tunable Resistive Sensing Pore. Current food-related research topics include multiple emulsions (W/O/W), protein-polysaccharide complexes, as well as heat stability of protein-stabilised emulsions, whereas stabilisation of nanosuspensions, as well as liposomal encapsulation are important aspects for pharmaceutical applications.
PaInT is currently headed by 2 senior academics and has a combined research and technical staff of around 20-25 members.
SynBioC, the research group of Prof. C. Stevens is focussing their activities along three research lines.
A first research theme is the synthesis and the development of synthetic methodology of small molecules for medicinal and agrochemical applications. Attention is paid to azaheterocyclic compounds and aminophosphonates as enzyme inhibitors and to the synthesis of natural product analogues.
Secondly, research is performed on continuous flow microreactor technology for scale up of reactions which are difficult to scale up under batch conditions.
A third research theme deals with the chemical modification of renewable resources to develop building blocks for the industry to stimulate the transition to a circular economy.
The research at the Laboratory of Pharmaceutical Technology (Ghent University) focuses on the development and fundamental characterization of novel drug delivery platforms, mainly for oral drug delivery with emphasis on sustained-release formulations and multiparticulate dosage forms.
As manufacturing technique continuous processing via wet granulation, direct compression and hot-melt extrusion is a major research topic at the department. An essential part of the research is the integration of monitoring tools during processing using various tools, in collaboration with the Laboratory of Pharmaceutical Process Analytical Technology at Ghent University.