Max. 15 people

COURSE OVERVIEW

This course gives an introduction on the (pharmaceutical) relevance of (raw) material characterization. An overview is given about the relevant characterization methods on the market, their applicability and how the material properties can be used to describe the processability.
This 1-day course consists out of a theoretical (interactive) and hands-on part.

MODULE 1: BASIC COURSE

Theoretical

The trainee will get an in-depth explanation about the different characterization methods, their (pharmaceutical) relevance and what you can do with the generated data.
Some of the key material characteristics described are:

Flow/cohesion
&
Particle size and shape
&
Density and porosity
&
Electrostatic charge
&
Melting point and crystal structure
&
Viscosity

Practical

Hands-on sessions will allow the trainee to get a feel with what it takes to characterize a material.
The extensive array of characterization equipments, available at CESPE, will be made available to visualize the difference between highly divergent powders.
Some of the equipment that will be used are:

FT4 Powder Rheometer
&
Schulze Ring Shear Tester
&
Granutools^TM equipment
&
Malvern Laser diffractors
&
DVS and DSC equipment

Upon request, a powder of interest could be tested on the available equipment!
For more information, please contact Sarah.Costers@UGent.be .

COURSE OVERVIEW

Twin screw granulation 101 focusses on giving a thorough introduction about the granulation process in an interactive manner (both theoretical and hands-on).
This course can be divided into three separate modules:

Module 1: Basic course: Introduction to twin screw wet granulation (1-day module)
&
Module 2: Basic course: Introduction to twin screw hot-melt granulation (1/2-day module)
&
Module 3: Specialized courses (1/2-day module)

MODULE 1: WET GRANULATION

Theoretical

The trainee will get an in-depth explanation about the basic twin screw wet granulation aspects such as:

Equipment overview
&
Principles of wet granulation
&
Batch vs continuous manufacturing
&
Process and formulation parameters
&
Granule characterization

Practical

The in-house ConsiGma^TM -25 line will be used to demonstrate the twin screw wet granulation process. Afterwards, the produced granules will be tested using the available granule characterization methods.
The hands-on session consists out of:

ConsiGma^TM-25 demonstration with placebo
&
Introduction to granule characterization methods

MODULE 2: HOT-MELT GRANULATION

Theoretical

The trainee will get an in-depth explanation about the basic twin screw hot-melt granulation aspects such as:

Equipment overview
&
Fundamentals of hot-melt granulation
&
Equipment configurations and settings
&
Pitfalls
&
Granule characterization*

*Will be skipped if module 1 was followed as well.

Practical

The trainee will be able to follow and help during placebo trials using a twin screw hot-melt granulator. The influence of process and formulation parameters will be demonstrated.

MODULE 3: SPECIALIZED COURSES

In this module, the goal is to highlight specific aspects of the granulation process through different use-cases. Each use-case allows the trainee to get an in-depth comprehension of a specific part of the process.

Topics

Wet granulation: Modified release formulations
&
Wet granulation: Impact of dry or wet addition

The trainee has the option to take up all of the provided topics, covering a half day course, or select a sub-set of these topics.

COURSE PROGRAM

A detailed overview of the different modules can be found in the following document.

Twin-screw-granulation-101 Download

If you are interested in following this course, please take a look at the planned sessions.
For further questions or requests, please use the contact form.