COURSE OVERVIEW
Towards Continuous Lyophilization course provides a comprehensive introduction to pharmaceutical freeze-drying through an engaging mix of theoretical and hands-on training.
This one-day course equips trainees with a solid understanding of the essential principles, covering the entire process from starting materials to the finished product.
This includes:
- formulation aspects
- getting to know the equipment
- learning to understand the first-principles of lyophilization
- including both heat and mass transfer mechanisms during freeze-drying
After that, the most important PAT tools which are commonly used in the field will be covered. Additionally, a novel continuous freeze-drying technology will be explored in detail. Finally, tour of the lab will be provided, along with interactive sessions on modeling and data analysis.
By the end of the course, participants will have a solid understanding of the key principles and processes involved in pharmaceutical freeze-drying. They will gain practical knowledge to design and optimize freeze-drying processes, select appropriate PAT tools, and troubleshoot common issues.
Theoretical
Introduction to Lyophilization
- Fundamentals of freeze-drying
- Detailed overview of the freeze-drying process
- Equipment and components used in freeze-drying
Lyophilization Formulations
- Purpose and composition of freeze-drying formulations
- Critical properties of freeze-dried materials
- Characterization methods for lyophilized products
Modeling the Freeze-Drying Process
- Introduction to modeling
- Modeling of freeze-drying and applications
- Design space for freeze-drying
Process Analytical Technology (PAT) in Freeze-Drying
- Importance of PAT in freeze-drying
- Key PAT tools and their application
Continuous Freeze-Drying
- Advantages and innovations of continuous freeze-drying
- Limitations of traditional batch freeze-drying
Practical
Tour of the CESPE Freeze-Drying Lab
- Batch freeze-dryers
- Continuous freeze-dryers
- Sample characterization lab
Interactive Modelling Session
- Hands-on experience in constructing a design space for freeze-drying
Data Analysis Workshop
- Interpretation and analysis of common freeze-drying data
COURSE PROGRAM
A detailed overview of the program can be found in the following document.
If you are interested in taking this course, please email Mark Gontsarik (mark.gontsarik@ugent.be).