The Laboratory of Pharmaceutical Biotechnology focusses on the analytical part of the two main biological large molecules: proteins and nucleic acids (DNA and RNA). Over the years we have gathered an extensive state of the art infrastructure and know-how for protein and proteome analysis, including high end mass spectrometry (ProGenTomics). On the genomics side a core facility with a strong focus on next generation sequencing technologies was created (nxtgnt). In order to manage and analyse the data we also have quite some bioinformatics expertise both in-house and available through collaborations.
Some topics of our research:
- Diagnosis of infectious diseases (SARS-CoV-2) by qualitative and quantitative use of mass spectrometry of proteotypic peptides after immunobased enrichment.
- Combining proteome analysis with histone proteome analysis, the latter focusses on identifying histone modifications in the context of epigenetic adaptations in stem and cancer cell development, potentially serving as biomarkers also as markers for developmental toxicity.
- Analysis (genomics) and isolation of rare (single) cells.
- Forensic and Archeological proteomics